In brief. Pyridoxal-5-phosphate (P-5-P/PLP) is a coenzyme form of vitamin B6; methylcobalamin is a biologically active form of vitamin B12. These terms describe specific molecules, but they do not prove universal clinical superiority. The NIH states that there is no evidence that vitamin B12 absorption from supplements varies by form. Eclo evidence rating: documented biochemical identity and nutritional functions; no basis for turning “active” or “methylated” into “necessarily better absorbed” or “better for everyone”.

What is P-5-P?

Vitamin B6 exists in several forms. Pyridoxal-5-phosphate is a coenzyme form involved in many enzymatic reactions. Naming P-5-P specifies the form present in the formula; by itself, it does not demonstrate better clinical outcomes than another B6 source.

What is methylcobalamin?

Vitamin B12 includes several cobalamins. Methylcobalamin and adenosylcobalamin are coenzyme forms used by the body. Cyanocobalamin and hydroxocobalamin can be converted into active forms.

The NIH Office of Dietary Supplements states that no evidence shows that absorption rates of supplemental B12 vary by form. The available data therefore do not support saying that methylcobalamin is globally superior to other forms for every user.

What can be said about vitamins B6 and B12 under EU regulation?

When content conditions are met, vitamins B6 and B12 have authorized European claims including contribution to normal energy-yielding metabolism, normal functioning of the nervous system, normal psychological function and reduction of tiredness and fatigue.

These claims apply to the nutrient, not to the superiority of P-5-P or methylcobalamin, and not to the clinical efficacy of Régénère™ or Ressource™.

Which forms does Eclo use?

In Régénère™, the reference composition includes:

Ressource™ also uses selected B-vitamin forms. The current regulatory product label remains the reference for quantities and applicable claims.

“Methylated vitamins”: what does the term really mean?

Marketing often groups 5-MTHF and methylcobalamin under this phrase. Methylation is a real set of biochemical reactions, but generic symptoms cannot diagnose a “methylation problem”. A methylated form is not, by itself, a treatment for a genetic polymorphism or a personalized recommendation.

Why document the form if it is not necessarily “better”?

Because raw-material identity is useful information. Transparency does not mean automatic hierarchy. Naming the form tells you what is actually in the capsule, then allows that fact to be separated from efficacy claims, which require their own evidence.

What we know — and what it does not allow us to conclude

• Documented: P-5-P is a coenzyme form of B6.
• Documented: methylcobalamin is an active form of B12.
• NIH: no evidence that absorption of supplemental B12 varies by form.
• Regulatory: B6 and B12 have authorized claims under conditions.
• Do not extrapolate: “active” does not mean clinically superior for everyone.
• Do not extrapolate: vitamin claims are not a study of the finished product.

Frequently asked questions

Is methylcobalamin better absorbed than cyanocobalamin?

That is not generally demonstrated. NIH states that no evidence shows different absorption rates by supplement form.

Is P-5-P an “active” form of B6?

Yes, in the biochemical sense: it is a coenzyme form. That does not prove universal clinical superiority.

Is a methylated vitamin necessary if someone has an MTHFR variant?

Not on that fact alone. Interpretation depends on clinical and nutritional context.

Why does Eclo specify these forms?

For formulation transparency, not to turn a chemical name into a promise.

Sources

• [Institutional reference] NIH Office of Dietary Supplements — Vitamin B6
• [Institutional reference] NIH Office of Dietary Supplements — Vitamin B12
• [Regulation] EU Regulation No 432/2012 — authorized health claims

Read next

Quatrefolic® and vitamin B9 · Understanding doses · How to read a clinical study · Régénère™ · Ressource™

Method note: chemical identity, a nutritional claim and a clinical benefit are different levels. Eclo does not turn the word “active” into evidence of superiority.

Last scientific review: 27 August 2026.